 AVICEL® RC/CLMicrocrystalline Cellulose and Carboxymethylcellulose Sodium USP/NF, BP, JPEAvicel RC/CL are water dispersible, colloidal, spray dried blends of microcrystalline cellulose and carboxymethylcellulose sodium used in pharmaceutical suspensions, emulsions, nasal sprays and creams. Avicel RC / CL products produce highly thixotropic, low viscosity, structured vehicles that yield desirable permanent suspensions without settling or sedimentation. It also eliminates lengthy hydration time while increasing formulation stability.
When used in reconstitutable suspensions, Avicel RC / CL facilitates hydration of the dry mix. Avicel dispersions are stable to heat and freeze/thaw over a wide pH range. Avicel thixotropy reduces the clearance of nasal spray formulations. It is an excellent stabilizer for oil-in-water emulsions, reducing oil droplet movement and coalescence. The wide range of thixotropies, viscosities, gel strengths, and dispersion characteristics of this product line provide unparalleled suspension stability and functional versatility.
| Grade | Description
| Application
| Avicel RC-581 | Bulk dried powder requiring high shear mixing for dispersion | Conventional suspending agent and dispersion aid. | | Avicel RC-591 | Spray dried powder requiring low shear mixing for dispersion | Used for oral suspensions, nasal sprays, topical sprays, lotions, liquid and semi-solid dosage forms. Provides a structured dispersion vehicle, acts as a protective colloid and facilitates dispersion. | | Avicel CL-611 | Spray dried powder requiring low shear mixing for dispersion. Has more CMC content
| Recommended for reconstitutable / dry suspensions. Also for oral suspensions. |
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