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Avicel PHMicrocrystalline Cellulose USP/NF, EP, JP
AAvicel PH, FMC’s innovator brand of microcrystalline cellulose, is a purified, partially depolymerized alpha-cellulose made by acid hydrolysis of specialty wood pulp and the process of polymerization involves high levels of quality and stringency.
Avicel PH’s unique properties – superior compactibility, drug carrying capacity and rapid disintegration - make it the excipient of choice in direct compression applications. When used in the wet granulation process, the risk of over-granulation is reduced, screen blockage is avoided and uniform, rapid drying is promoted. The distinct properties of this excipient also benefit the dry granulation processes of roller compaction and slugging. Avicel PH is an excellent extrusion-spheronization binder and its inclusion in capsule formulations improves flow, facilitates plug formation and aids capsule disintegration. With the development of differentiated grades, Avicel PH remains an indispensible formulation tool, boosting productivity and meeting tough formulation challenges. | Grade | Description
| Application
| Avicel PH ‐ 101 | Fine particle size | For conventional applications, specially in wet granulation and roller compaction. | | Avicel PH ‐ 102 | Medium particle size | For improved flow in direct compression, dry phase of wet granulation and dry granulation. | | Avicel PH ‐ 103 | Low moisture with fine particle size | Well suited for moisture sensitive actives. | | Avicel PH ‐ 105 | Extra fine particle size | For use in direct compression of coarse or hard‐to‐compress materials. | | Avicel PH ‐ 112 | Very low moisture with medium particle size | Best for direct compression of moisture sensitive actives with increased flow. | | Avicel PH ‐ 113 | Very low moisture with fine particle size | Improves product stability by extending the shelf life, particularly of moisture sensitive actives. | | Avicel PH ‐ 200 | Largest particle size | For best flow in direct compression and dry granulation applications while maintaining high levels of compressibility with minimum weight variation and content uniformity issues. | | Avicel PH ‐ 200 LM | Very low moisture with largest particle size | Best for direct compression of moisture sensitive actives with superior flow rate than PH ‐ 112. | | Avicel PH ‐ 301 | High bulk density with fine particle size | For manufacture of small tablets. reduces powder stratification and tablet weight variation by efficient mixing. | | Avicel PH ‐ 302 | High bulk density with medium particle size | For manufacture of thin tablets despite high API content. Prevents powder segregation and gives good flow. |
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