FMCBiopolymer

Avicel® PH

Microcrystalline Cellulose USP/NF, EP, JP


Avicel PH is the innovator’s brand of microcrystalline cellulose. It is a purified, partially depolymerized alpha-cellulose made by acid hydrolysis of speciality wood pulp controlled to a stringent degree of polymerization than required by global pharmacopeia.

The unique properties of Avicel PH makes it an indispensable formulation tool and excipient of choice in direct compression applications on account of its superior compactibility, drug carrying capacity and rapid disintegration. These properties also benefit dry granulation process such as roller compaction or slugging. When used in wet granulation process, Avicel reduces the risk of over-granulation, avoids screen blockage and promotes uniform, rapid drying. Avicel PH is an excellent extrusion-spheronization binder. The inclusion of Avicel PH in capsule formulations improves flow, facilitates plug formation and aids capsule disintegration.

Avicel PH continues to set new standards with enhanced grades designed to boost productivity and meet any formulation challenge.

Grade Description
 Application

Avicel PH ‐ 101

Fine particle size

For conventional applications, specially in wet granulation and roller compaction.
Avicel PH ‐ 102 Medium particle size For improved flow in direct compression, dry phase of wet granulation and dry granulation.
Avicel PH ‐ 103 Low moisture with fine particle size Well suited for moisture sensitive actives.
Avicel PH ‐ 105 Extra fine particle size For use in direct compression of coarse or hard‐to‐compress materials.
Avicel PH ‐ 112 Very low moisture with medium particle size Best for direct compression of moisture sensitive actives with increased flow.
Avicel PH ‐ 113 Very low moisture with fine particle size Improves product stability by extending the shelf life, particularly of moisture sensitive actives.
Avicel PH ‐ 200 Largest particle size For best flow in direct compression and dry granulation applications while maintaining high levels of compressibility with minimum weight variation and content uniformity issues.
Avicel PH ‐ 200 LM Very low moisture with largest particle size Best for direct compression of moisture sensitive actives with superior flow rate than PH ‐ 112.
Avicel PH ‐ 301 High bulk density with fine particle size For manufacture of small tablets. reduces powder stratification and tablet weight variation by efficient mixing.
Avicel PH ‐ 302 High bulk density with medium particle size For manufacture of thin tablets despite high API content. Prevents powder segregation and gives good flow.