Ashland Aqualon

BLANOSE®

Sodium Carboxymethylcellulose USP/NF, EP, JP


BLANOSE, Carboxymethylcellulose Sodium is the sodium salt of carboxymethylcellulose (CMC) which is an anionic, water-soluble polymer derived from cellulose reacted with sodium monochloroacetate. BLANOSE is soluble in cold or hot water, insoluble in organic solvents, compatible with water / alcohol systems & imparts low water and oxygen transmission to coatings.


BLANOSE grades find application as thickeners, binders, stabilizers, suspending agents and rheology modifiers. The grades designated P or PH are purified grades which meet pharmaceutical standards. A wide range of substitution types are also available, based on number of carboxymethyl groups present on the cellulose backbone. The low substitution grades (7 types) provide thixotropy whereas the higher substitution grades (9 and 12 types) provide smooth solutions without thixotropy.


Grade Viscosity in mPas (% w/w)*
Application

Blanose 7H4F-PH

2500 - 4500 (1%)

Tablet coatings - Film former


Mucoadhesives - Absorbency


Syrups & Suspensions - Thickener & suspending agent


Sustained Release - Thickener, diffusion barrier


Bulk Laxative - Inert, high water binding agent


Ointments, Creams & Lotions - Stabilizer, thickener, film former

Blanose 7HF-PH 1500 - 2500 (1%)
Blanose 7MF-PH 400 - 600 (2%)
Blanose 7M1F-PH 50 - 100 (2%)
Blanose 7LF-PH 25 - 50 (2%)
Blanose 9M31F-PH 1500 - 3100 (2%)
Blanose 9M8F-PH 400 - 800 (2%)
Blanose 12M8P 200 - 800 (2%)
Blanose 12M31P 1500 - 3100 (2%)
*Also avaialbe in finely (X) ground grades.

*Viscosity in milli Pascal per second (mPas or cps) determined on aqueous solutions as per indicated weight %. at 250 C + 0.50 C using a Brookfield ‐ Syncro‐Lectric LVF viscometer.


DS‐Type Substitution range
Sodium content, %

7

0,65 to 0,90 **

7,0 - 8,9

9 0,80 to 0,95 9,2 - 9,3
12 (for USP grades) 1,15 to 1,45 10,4 - 12,0
12 (for EP grades) 1,12 to 1,21 10,2 - 10,8
** in 7S and 7O types, the upper limit of substitution is 0,95.