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CALCIUM PHOSPHATES
Calcium phosphates are widely used in pharmaceutical formulations as capsule or tablet diluents. It has many positive characteristics as an excipient including good compressibility, excellent stability and white colour. Due to their inherent property of good compatibility, they find use in both direct compression and wet-granulation process. Two particle size grades of calcium phosphate are available. The “Milled” or “Powder grade” is typically used in wet granulation process or roller compaction while the “Unmilled” or “Granular grade” is used in direct compression process due to its good flow properties.
Granular grades USP/NF, EP, JP
| Grade | Description
| Application
| A-Tab® | Dibasic calcium phosphate Anhydrous | Tablet and capsule diluent / filler, used in direct compression. Non-hygroscopic, stable at room temperature adding to better product stability. Source of calcium and phosphorous. | | Di-Tab® | Dibasic calcium phosphate Dihydrate
| Tablet and capsule diluent / filler, used in direct compression. Flow agent, blend densifier, tablet punch polishing agent, time release agent and carrier of actives. Source of calcium and phosphorous.
| | Tri-Tab® | Tribasic calcium Phosphate Anhydrous
| Tablet and capsule diluent / filler, used in direct compression and as filler – binder in vitamin – mineral formulations. Also used as a glidant due to high surface area and carrier of actives. Higher calcium and phosphorous content.
| | Tri-Cal® WG | Tribasic calcium phosphate Anhydrous
| Special high density grade for use in wet granulation. Benefits similar as Tri-Tab.
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