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CALCIUM PHOSPHATES
Calcium phosphates are widely used in pharmaceutical formulations as capsule or tablet diluents. It has many positive characteristics as an excipient including good compressibility, excellent stability and white colour. Due to their inherent property of good compatibility, they find use in both direct compression and wet-granulation process. Two particle size grades of calcium phosphate are available. The “Milled” or “Powder grade” is typically used in wet granulation processes or roller compaction while the “Unmilled” or “Granular grade” is used in direct compression processes due to its good flow properties.
Powder grades USP/NF, EP, JP
| Grade | Description
| Application
| Calipharm® A | Dibasic calcium phosphate Anhydrous | Filler in wet granulation, multivitamin chewable tablets and nutritional drinks. | | Calipharm® D | Dibasic calcium phosphate Dihydrate. | Filler in wet granulation, vitamin premixes and nutritional drinks. | | Calipharm® T | Tribasic calcium phosphate Anhydrous | Filler in wet granulation, particularly antacid formulations for its buffer action. Also used in nutritional drinks and calcium / phosphorous fortifications. |
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