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CREMOPHOR®
Non-ionic solubilizers / Emulsifiers
Cremophor RH 40 is a non-ionic solubilizer and emulsifying agent obtained by reacting 45 moles of ethylene oxide with one mole of hydrogenated castor oil.
Cremophor EL is a non ionic solubiliser and emulsifier made by reacting castor oil with ethylene oxide in a molar ratio of 1:35. Cremophor ELP is a purified grade of Cremophor EL specially developed to give stable formulations of sensitive APIs, especially in injectable form.
The Cremophor A types are prepared by reacting higher saturated fatty alcohols with ethylene oxide, with the degree of ethoxylation being indicated by the numeral in the name.
| Grade | Pharmacopoeial Name | Appearance
| Application
| Cremophor RH 40 | Polyoxyl-40
Hydrogenated Castor Oil | White to yellowish, nearly odourless, tasteless, paste | Used to solubilize vitamins, hydrophobic actives, and essential oil-in-water or hydroalcoholic
mixtures, to improve bioavailability in solid
dosage forms and as solubilizer in oral / topical liquid and semi-liquid dosage forms. | | Cremophor EL | Polyoxyl-35 Castor Oil
(Standard grade) | Pale yellow oily liquid | | Cremophor ELP | Polyoxyl-35 Castor Oil
(Extra pure grade of EL). | White to yellowish paste or cloudy liquid | Used as solubilizer and emulsifier in
liquid formulation for oral, topical and parenteral use. | | Cremophor A 6 | Macrogol-6-cetostearyl
ether | Whitish waxy substance | Non-ionic emulsifiers used for production of ointments, creams, gels based on oil-in water
emulsions / water-in-oil emulsions. Also used
for emulsification of hydrophobic APIs to
form very stable oil‐inwater emulsions. | | Cremophor A 25 | Macrogol-25-cetostearyl
ether | Free flowing, nondusting micro beads |
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