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KOLLIDON®
Povidone USP/NF, EP, JP The Kollidon range consists of soluble polyvinyl pyrrolidone which is obtained by radical polymerization of N-vinylpyrrolidone in water or isopropanol under cGMP conditions to yield the chain structure constituting polyvinylpyrrolidone (PVP). By virtue of it’s solubility in water and many organic solvents, it’s high binding power and ability to form complexes, soluble PVP occupies a special position among the synthetic colloids.
Kollidon is available in different grades on the basis of their K-value and molecular weight. All grades are supplied as almost white, free flowing, tasteless powders with a slight characteristic odour in pharmaceutically pure form.
| Grade | Description
| Application | | K‐value | Molecular weight (Mw) | Kollidon 12 PF | 10.2 - 13.8 | Low (2000-3000) | Pyrogen free grade, used as solubilizing, stabilizing agents, dispersants and crystallization inhibitors particularly for injectables; especially antibiotics in solution or lyophylisate form. | | Kollidon 17 PF | 15.3 - 18.0 | Low (7000-11000) | Same as Kollidon 12 PF. Can be additionally used as solubilizer, film former or thickener in ophthalmic preparations. | | Kollidon 25 | 22.5 - 27.0 | Medium (28000 - 34000) | Versatile and widely used as binders in tablets, capsules and granules, stabilizers in oral suspensions, film formers, dispersants for pigments, thickeners and bioavailability enhancers | | Kollidon 30 | 27.0 - 32.4 | Medium (44000 - 54000) | | Kollidon 90 F | 81.0 - 96.3 | High (1000000 - 1500000) | Highly effective binder for wet and dry granulation; stabilizer and thickener for oral and topical solutions including ophthalmic preparations. |
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