|
KOLLIDON® CL
Crospovidone USP/NF, EP, JPE Crospovidone grades are the insoluble grades of Povidone manufactured by a polymerization process that yields crosslinked insoluble polyvinylpyrrolidone in the form of a “popcorn” polymer. The polymerisation is performed using an aqueous system.
Crospovidones are “Super Disintegrants” completely insoluble in solvents. In contrast to many other disintegrants they are also non-water soluble. As a consequence, there is no influence on the disintegration of a tablet and the dissolution of the active due to the increased viscosity. The crosspovidones act as disintegrants by absorbing water and subsequently swelling. This gain in volume is responsible for the subsequent disintegration of the tablet. The different Kollidon CL are distinguished by their different particle sizes.
| Grade | Description
| Application
| Kollidon CL | Standard grade | Used as a tablet disintegrant and for improving the release of active substances from tablets, capsules and granules. | | Kollidon CL-F | Fine particle size grade | Used as disintegrant in tablets, especially in formulations for small tablets and in wet granulation (less content uniformity problems). | | Kollidon CL-SF | Superfine particle size grade | Used as disintegrant in fast dispersible tablets for a smooth mouth-feel. | | Kollidon CL-M | Micronized grade | Used as a stabilizer for oral and topical suspensions and for improving the release of active substances from tablets, capsules and granules. |
|
