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KOLLIDON CL
Crospovidone USP/NF, EP, JPE The insoluble grades of Kollidon are crosslinked polyvinylpyrrolidone manufactured by a polymerization process using an aqueous system, yielding crosslinked insoluble PVP in the form of a ‘popcorn’ polymer.
Kollidon CL grades are used as ‘superdisintegrants’ due to their property to swell very fast and predictably without forming a gel. These grades accelerate the dissolution and the bioavailability due to its power to form complexes with many insoluble actives.
| Grade | Average particle size range (µm)
| Applications
| Kollidon CL | 110 - 130 | Standard grade, for use as a tablet disintegrant and for improving the release of active substances from tablets, capsules and granules. | | Kollidon CL-F | 20 - 40 | Fine particle size grade, for use as a disintegrant in tablets, especially in formulations for small tablets and in wet granulation. | | Kollidon CL-SF | 10 - 30 | Super-fine particle size grade for use as a disintegrant in fast dispersible tablets due to its smooth mouth feel. | | Kollidon CL-M | 3 - 10 | Micronized particle size grade used as a stabilizer for oral and topical suspensions and for improving the release of active substances from tablets, capsules and granules. |
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