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L-HPC
Low substituted Hydroxypropyl Cellulose USP/NF, JP L-HPC is a low-substituted hydroxypropyl ether of cellulose. It is non-ionic and less reactive to active ingredients. It is insoluble in water and alcohols but swells in water. It causes changes in the binding and disintegrating characteristics as a result of subtle changes in its physical properties like particle size and substituent content. Hence, it is widely used as a dual-functional excipient (disintegrant / binder) for tablets, granules or other pharmaceutical solid dosage forms.
| Grade | Description | Application | | Mean particle size (μm) | Particle type | L‐HPC LH-11 | 50 | Highly fibrous | Direct Compression (anticapping). | | L‐HPC LH-21 | 40 | Moderately fibrous | Regular grade (dry mixing, wet granulation). | | L‐HPC LH-22 | 40 | Moderately fibrous | Lower hydroxypropoxy content (sometimes better
disintegration). | | L‐HPC LH-31 | 20 | Micronized | Micronized grade (Pellet extrusion, layering). | | L‐HPC LH-32 | 20 | Micronized grade with lower hydroxypropoxy content (Pellet extrusion, layering). | | L‐HPC LH-B1 | 50 | Non fibrous | High density grade suitable for direct compression with good flowability and high loading capability. | * Laser diffraction method
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