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LUTROL® F
Poloxamer USP/NF, EP, JPE The Lutrol F grades or Poloxamers are block copolymer of polyoxyethylene polyoxypropylene (Pluronics). While Lutrol F 68 (Poloxamer 188) is a white to slightly yellowish, waxy substance in the form of microbeads with a faint odour, Lutrol F 127 (Poloxamer 407) is a white, coarse-grained powder with a waxy consistency. Both grades are soluble in ethanol and water.
The Lµtrol® micro grades - Lµtrol F micro 68 and Lµtrol F micro 127 are white, micronized Poloxamer powders of average particle size of ~50 µm. with a weak odour.
| Grade | Description
| Application
| Lutrol F 68 | Poloxamer 188 (Block polymer of 81% polyethylene glycol and 19% polypropylene glycol) with an average molecular weight of 8600 | Emulsifier, solubilizer and suspension stabilizer in liquid, oral, topical and parenteral dosage forms, as a plasticizer and bioavailability enhancer in solid preparations. Also as co‐emulsifier in creams and emulsions and as a tablet lubricant. | | Lμtrol Micro 68 | Micronized Poloxamer 188 with a mean particle size of 50 μm for homogenous mixing | Dissolution enhancer for actives in solid oral dosage forms; water soluble lubricant for effervescent tablets and for actives incompatible with stearates. | | Lutrol F 127 | Poloxamer 407 (Block polymer of 73% polyethylene glycol and 27% polypropylene glycol with an average molecular weight of 12,000 | Gel former, thickening agent and solubilizer in oral and topical solutions and as a stabilizer in topical suspensions. | | Lμtrol Micro 127 | Micronized Poloxamer 407 with a mean particle size of 50 μm for homogenous mixing | Dissolution enhancer for actives in solid oral dosage forms; water soluble lubricant for effervescent tablets and for actives incompatible with stearates. |
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