Shin-Etsu


METOLOSE®

Hypromellose (HPMC) USP/NF, EP, JP
Methylcellulose (MC) USP/NF, EP, JP

 

MMetolose is a nonionic, water soluble cellulose ether derived from highly purified natural pulp by initial treatment with caustic soda to obtain alkalicellulose, followed by etherification with methyl chloride or with the combination of methyl chloride and propylene oxide.

It can be used as a binder for solid dosage forms and enjoys a variety of properties such as water retention, thickening, sustainedrelease, protective colloid, etc.

Metolose consists of methylcellulose and three substitution types of hypromellose each available in several grades of differing viscosity. ShinEtsu also manufactures Metolose SR grades specifically for use in hydrophilic sustainedrelease matrix systems.

Grade Description Application
Viscosity (cPs)
USP Substitution
Type

Metolose 60SH-50

50

2910

HPMC polymer, used as a sustainedrelease agent, thickener, suspending agent and binder for tablets and granules. Also used for ophthalmic formulations

Metolose 60SH-4000 4000
Metolose 60SH-10000 10000
Metolose 65SH-5050
2906
Metolose 65SH-4000 4000
Metolose 90SH-4000 4000 2208
Metolose 90SH-15000 15000
Metolose 90SH-100000 100000
Metolose 90SH-100SR 100 Special HPMC grade, used as hydrophilic matrix agents allowing more controllable and reproducible drug release, along with good consistency in the final product
Metolose 90SH-4000SR 4000
Metolose 90SH-15000SR 15000
Metolose 90SH-100000SR 100000
Metolose SM-4 4 - Methylcellulose polymer for granule coating Methylcellulose polymer used as a granulating agent, emulsifying agent, thickener and bulk laxative
Metolose SM-15 15 -
Metolose SM-400 400 -
Metolose SM-4000 4000 -