Signet - Avicel PH - Microcrystalline Cellulose (MCC)

AVICEL® PH

Microcrystalline Cellulose USP/NF, EP, JP, BP

Avicel PH is purified, partially depolymerized alpha cellulose derived from purified speciality grades of wood pulp. The unique properties of Avicel PH makes it an indispensable formulation tool. It is the excipient of choice for direct compression formulations, lending superior compactibility, drug carrying capacity and rapid disintegration. These properties also benefit dry granulation processes such as roller compaction or slugging. When used in wet granulation processes, Avicel reduces the risk of overgranulation, avoids screen blockage and promotes uniform, rapid drying. Avicel PH is an excellent extrusion-spheronization binder. The inclusion of Avicel PH in capsule formulations improves flow, facilitates plug formation and aids capsule disintegration.

GRADE	DESCRIPTION	APPLICATION
Avicel® PH - 101	Standard grade with medium particle size	For conventional applications, especially in wet granulation and roller compaction
Avicel® PH - 102	Standard grade with large particle size	For improved flow in direct compression, the dry phase of wet granulation and dry granulation
Avicel® PH - 103	Low moisture content with fine particle size	Well suited to moisture-sensitive drugs
Avicel® PH - 105	Extra fine particle size	For use in direct compression of coarse or hard-to-compress materials
Avicel® PH - 112	Very low moisture content with large particle size	For increased flow in direct compression with moisture-sensitive ingredients
Avicel® PH - 113	Very low moisture content with fine particle size	Helps extend shelf life and improve final product stability especially with moisture-sensitive drugs
Avicel® PH - 200	Very large particle size	For best flow rate in direct compression and dry granulation maintaining high levels of compressibility and minimizing problems of weight-variation and content uniformity
Avicel® PH - 301	High bulk density with fine particle size	Reduces powder stratification, helps mixing of fine actives and facilitates making smaller tablets
Avicel® PH - 302	High bulk density with large particle size	Avoids powder segregation, achieves good flow rates and can be used for high dose formulations to produce thin tablets