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KOLLIDON®
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| Polyvinylpyrrolidone
(PVPK) USP/NF, EF, JP
The soluble
grades of Kollidon are obtained by free-radical polymerization
of vinylpyrrolidone in water or isopropanol according to the
cGMP regulations, yielding the chain structure of polyvinylpyrrolidone
[1,141]. Because of its solubility in water and many organic
solvents, it’s high binding power and ability to form
complexes, soluble PVP occupies a special position among the
synthetic colloids. Kollidon is available in a wide range
depensing in their K-value and molecular weight.
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| GRADE |
DESCRIPTION |
APPLICATION |
K-Value |
Molecular
Weight |
| Kollidon
12 PF |
10.2
- 13.8 |
Low |
Low
Pyrogen free grades for use as solubilzer, crystallization inhibitor,
suspension stabilizer and lyophilization agent in injections
and ophthalmic preparations. |
| Kollidon
17 PF |
15.3 - 18.0 |
Low |
| Kollidon
25 |
22.5 - 26.7 |
Medium |
Versatile
and widely used as binders in tablets, capsules & granules,
stabilizers in oral suspensions, film formers, dispersants for
pigments, thickeners and bioavailability improvers |
| Kollidon
30 |
27.0 - 32.1 |
Medium |
| Kollidon
90 PF |
81.0 - 96.3 |
High |
A
highly effective binder, stabilizer for oral and topical suspensions,
thickener, hydrophilizer and pore former in medical devices |
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