Polyvinyl Acetate and Povidone based excipient

Kollidon SR, an excipient for drug delivery matrices based on Polyvinyl acetate, possesses good controlled release properties. The release profiles of tablet formulations with Kollidon SR were not influenced by different dissolution media or compression forces. The excellent flow properties and the dry binding activity of Kollidon SR, provide easy handling and effective development and production of sustained release tablets. By applying low compression force floating tablets with a longer residence time in the stomach can be achieved. Floating times exceeding 24 hrs can be achieved easily. Furthermore it can be shown that even for low compression forces dissolution is independent of the pressure applied.