Signet - L- HPC

L - HPC®

Low substituted Hydroxypropyl Cellulose USP/NF, EP, JP

L-HPC is a low substituted Hydroxypropyl ether of cellulose. It is insoluble in water and solvents but swells in water. It causes changes in the binding and disintegrating characterisitcs as a result of subtle changes in physical properties. Thus, it is widely used as dual-functional excipient (disintegrant/binder) for tablets, granules or other pharmaceutical solid dosage forms.

GRADE	DESCRIPTION		APPLICATION
GRADE	*MEAN PARTICLE SIZE (µm)**	PARTICLE TYPE	APPLICATION
L-HPC LH-11	50	Highly fibrous	Direct Compression (anti-capping)
L-HPC LH-21	40	Moderately fibrous	Regular grade (dry mixing, wet granulation)
L-HPC LH-31	20	Micronized	Micronized grade (pellet extrusion, layering)
L-HPC LH-B1	50	Non fibrous	High bulk density grade used in direct compression or fluid bed granulation process especially for high load formulations.

* Laser diffraction method